18.97.14.88
18.97.14.88
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Paradoxical expression of p16 in eccrine porocarcinoma that developed synchronously with basal cell carcinoma
( Tae Lim Kim ) , ( Young Wook Ko ) , ( Won Seon Koh ) , ( Jeong Eun Kim ) , ( Jooyeon Ko ) , ( Young Suck Ro )
UCI I410-ECN-0102-2018-500-004087130
This article is 4 pages or less.

Eccrine porocarcinoma (EP) usually develops in a longstanding eccrine poroma and is found after progression. P16 is a tumor suppressor protein that decelerates cell cycle. Due to its paradoxical overexpression in some malignancies, it is used as a marker for early detection of cancers. A 77-year-old woman presented with blackish ulcerative plaque on forehead and bluish to grayish nodule on left temporal scalp. Serous discharge and bleeding accompanied on the forehead for 10 months. The temporal lesion was incidentally found during physical examination. Histopathologic examination from the forehead showed basaloid tumor islands with peripheral palisading and peritumoral lacunae. A biopsy from the temporal scalp showed a protruding tumor mass downward in continuity with epidermis. The tumor cells were homogenous poroid cells that are positive for epithelial membrane antigen (EMA). The mitotic figures, enlarged hyperchromatic nuclei, infiltration to surrounding tissue, and necrosis were focally observed. Additional stain for p16 protein revealed overexpression on cytoplasm of the tumor cells. Based on these findings, the diagnosis of synchronous BCC and EP of the head were made. Herein, we report a rare case of EP that concurred with basal cell carcinoma (BCC) diagnosed with p16 stain.

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