Minocycline-induced nail pigmentation is an uncommon side-effect. Most of the cases show blue-black or slate-gray discoloration of the proximal nail beds, and some cases reveal longitudinal melanonychia. These symptoms usually occur after prolonged minocycline therapy, mostly longer than a few years, and coincide with other pigmented sites. We report herein two patients developing blue-gray nail discoloration alone after short term minocycline therapy. One patient is a 56-year-old female and the other patients is a 21-year old female. Both patients with rosacea had been treated with 100mg minocycline twice daily for 8 weeks when they developed a change in the color of their proximal fingernails. No pigmentation was found elsewhere on the skin, mucous membranes, teeth or sclera. These cases demonstrate that nail pigmentation can also occur after relatively short term minocycline therapy. In addition, our cases suggest the possibility that nail discoloration may occasionally precede other pigmentary changes. It is important to observe nails of patients taking minocycline.