Yellow Nail Syndrome (YNS) is a rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. It is chracterized by yellow nail discoloration, pulmonary manifestations, and lower limb lymphedema. Nail manifestation includes slow growth, thickening, hardening, transversal ridging, onycholysis, onychorrhexis, and paronychia. Pulmonary manifestation shows bronchitis, bronchiectasis, pneumonia, and pleural effusions. Chronic sinusitis is frequently associated with the triad of YNS. A 61-year-old male visited our clinic with nail dystrophy which started 18 months ago. Nail changes were observed including nail thickening, yellow color change, and transverse ridging. Result of potassium hydroxide (KOH) preparation, and fungus culture were negative. Periodic acid-Schiff (PAS) staining of nail clipping specimen revealed no fungal hyphae. There had been history of bronchiectasia with bronchiolitis, pneumonia, and chronic sinusitis. The patient had also experienced myocardial infarction (MI) and hypothyroidism. Herein, we present a very rare case of YNS with both MI and hypothyroidism.