Acute cutaneous lupus erythematosus (ACLE) shows localized eruption like malar rash or generalized form involving diffuse maculopapular erythema. Rarely, ACLE present with Stevens-Johnson syndrome (SJS) / toxic epidermal necrolysis (TEN)-like vesiculobullous eruption in most severe form. A 55-year-old female presented with gradually progressive erythematous maculopatch, blisters, and erosions over face, neck, and trunk for 2 weeks. Erosion and crust were observed in oral mucosa, but ocular and genital mucosa was intact. The patient was diagnosed with SLE 2 months ago and showed gradual improvement of the disease with systemic prednisolone medication. The skin lesion was similar with SJS but no relevant medication had been newly administered. Histopathologic finding showed full thickness epidermal necrosis and dense lymphocytes infiltration in the dermis. Laboratory tests demonstrated thrombocytopenia, low C3 complement, and increased anti-double-stranded DNA that indicated flare up of SLE. Slow progression, sun-exposed distribution with limited mucosal involvement, and laboratory findings indicated that SJS-like skin lesion was not caused by drug, but flare up of SLE in this patient. Herein, we report a rare case of SJS-like SLE and reinforce in a small proportion of SJS patients could be the presentation of flare up of SLE.