Fixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. A 47-year-old woman presented with painful, solitary, 7㎝-sized blistering eruption with surrounding erythema affecting the right sole. 2 weeks before the appearance of the lesion, she was prescribed naproxen/esmeprazole from the orthopedics department for knee pain. After ingestion of the prescribed medicine, tense bulla was observed. She stopped taking the medication and after simple dressing, the lesion improved. One week later, after taking the same pills, the lesion was recurred. Skin biopsy was carried out at the peripheral side of the lesion. Histological examination revealed subepidermal blister formation and lymphohistiocytic, eosinophil infiltration at the epidermis, papillary and reticular dermis. The patient was treated with topical steroid for 1 week along with cessation of naproxen/esmeprazole. On follow-up, resolution of the lesions with surrounding hyperpigmentation was examined. The bullous FDE located on the soles can be confused with friction blister or bullous type tinea pedis. Herein we report a case of bullous fixed drug eruption on the sole. Clinicians must be aware of the possibility of bullous FDE if a patient has the corresponding drug history.