18.97.14.88
18.97.14.88
close menu
Non-Langerhans cell histiocytosis: generalized eruptive histiocytosis and benign cephalic histiocytosis
( Seon Gu Lee ) , ( Seung Hui Seok ) , ( Ji Hae An ) , ( In Jae Jeong ) , ( Hee Jung Lee ) , ( Moon Soo Yoon ) , ( Dong Hyun Kim )
UCI I410-ECN-0102-2018-500-004084826
This article is 4 pages or less.

Non-langerhans cell histiocytosis (NLCH) represents a broad group of different disorders characterized by the proliferation of histiocytes other than Langerhans cell. Generalized eruptive histiocytosis (GEH) and benign cephalic histiocytosis (BCH) belongs to NLCH, BCH is considered a limited form of the GEH. GEH is characterized by an asymptomatic, symmetric eruption of pink or dark red papules on the face, trunk and proximal extremities. BCH manifests as similar pattern of skin rashes distributed mainly on the head, face, neck and shoulders of infants and children. A 3-year-old girl visited our clinic with 2-year history of multiple 2-5mm sized yellowish papules on the face. A punch biopsy specimen revealed diffuse histiocytic infiltration in upper dermis. Immunohistochemically, the histiocytes are positive for CD68, negative for CD1a and S-100. BCH was diagnosed with consideration of histopathologic, immunohistochemical features and rashes limited to the face. A 16-year-old woman presented with multiple symmetrically distributed 3-10mm sized red to brown papules on the face, trunk and both extremities which developed 1 year ago. Histopathology also showed dermal infiltration of monomorphic histiocytes which were positive for CD68, but negative for CD1a and S-100. The patient was diagnosed with GEH. Both patients are under observation without other treatments. Herein, we report two cases of NLCH with review of literature.

[자료제공 : 네이버학술정보]
×