Scarring after severe inflammation is a common cosmetic problem accompanied by psychological distress. There is no gold standard treatment for post inflammatory scars, and many physicians seek for optimal combination therapy. Recently, some studies have shown efficacy of fractional microneedle radiofrequency for the treatment of scars, however reports of combination therapies are limited. A female patient complained of depressed scar formation on left V1 and V2 dermatome after herpes zoster. The patient received treatment of microneedle radiofrequency device and adjuvant polydeoxyribonucleotide injection every 2-3 weeks. After 5 sessions of treatment significant improvement was seen and the patient was very satisfied. Another patient complained of depressed and hypertrophic scar formation on forehead and neck after deep fungal infection. This patient also received combination treatment and after 5 sessions of treatment and the clinical improvement was significant. Polydeoxyribonucleotide(PDRN) which was known for boosting of neocollagnesis was used as the adjuvant therapy in these cases. PDRN may be a beneficial option to promote wound healing of post-needling site and reduce side effects of postinflammatory hyperpigmentation. A treatment of microneedle radiofrequency device with PDRN injection may be a safe and effective combination treatment for severe inflammatory scars.