Objectives: The aim of this study was to examine factors influencing health-related quality of life in women workers using the dataset of the Korean National Health and Nutritional Examination Survey (KNHANES 2th). There were 955 subjects. Methods: A multiple regression model was used to study the factors influencing health-related quality of life of women workers. Results: A positive relationship was found between education (b=0.014, p=0.029) and health-related quality of life in women workers and non-osteoarthritis (b=0.037, p<0.001) and health-related quality of life in women workers. Conclusions: The results of this study show the importance of improving the working environment and preventing osteoarthritis in non-regular employment.