PURPOSE: To evaluate the effects of low-load resistance exercise (RE) with intermittent blood flow restriction (BFR) on the muscle thickness, blood lactate, creatine kinase (CK) and thiobarbituric acid-reactive substance (TBARS) levels in male. METHODS: The study included 10 male college students aged 23.5±1.0 years who underwent the following experimental protocols in random order on separate days (72 hour): 3 sessions at a 30% one-repetition maximum (1RM) RE with BFR (individual systolic blood pressure, 150% systolic blood pressure and 200% systolic blood pressure); 1 session at 60% 1RM RE without BFR (CON). The thigh circumference, TBARS and CK levels were measured before exercise (pre-exercise) and post-exercise and lactate, heart rate (HR), systolic (SP) and diastolic blood pressure were measured pre-, post-exercise, 5-, 15- and 30-minutes recovery. RESULTS: Thigh circumference significantly increased following 30% 1RM with SP (p=.10) and SP 200% (p=.36) BFR compared to 60% 1RM without BFR but there was an increasing tendency in 30% 1RM with SP 150% (p=.83) BFR. Additionally, there were significant increases in TBARS (p<.05) and CK (p<.05) in the all protocols post-exercise samples compared with the pre-exercise samples but no significant group (p=.113, p=.870, respectively) or interaction (p=.385, p=.132, respectively) effect. CONCLUSIONS: 30% 1-RM with BFR may effectively increase the circumference of the thigh muscle compared to 60% 1RM without BFR. Although both 30% 1RM with BFR (SP, SP 150%, SP 200%) and 60% 1RM without BFR temporarily increased TBARS production and CK, It does not cause damage.