The purpose of this study is to suggest a direction for the development of unique nail art design by studying the cartoon images of neo-pop art and using them in nail art. This study analyzed the works of neo-pop artists Romero Britto, Takashi Murakami and Keith Haring. Nail art works were designed by 3D art, hand painting and stencil, using UV gel, glitter, stone, silk eyelash, etc. The study results found the followings: First, the characteristics of cartoon images were derived with simplicity, color diversity and symbolic meaning after analyzing neopop artists’ works based on the previous studies. In the cartoon images in neo-pop artists’ works, the outline was emphasized with a bold line in terms of shape simplicity. The shape was simplified, or characters were expressed repeatedly. In color diversity, images were expressed using diverse colors in a single work. Then, the uniqueness of the design was emphasized, and certain feature of the character was expressed. Time expression and message delivery were carried out. In the symbolic aspect of the meaning, the characters, background, signs and letters used in the design were verbalized to symbolize the meaning the artists wanted to deliver to the public. Second, works were selected (2 works per artist), and motives were set. Using cartoon images, a total of 6 nail art works were designed. The shapes were simplified, or characters were repeatedly used. Based on a strong primary color, at least 7 different colors were used, creating symbolic meaning.