18.97.14.85
18.97.14.85
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SCOPUS
제어 방출형 캅토프릴 마이크로캅셀의 제조 및 용출 특성
The Preparation of Controlled-Release Microcapsules for Captopril and Their Dissolution Characteristics
최현순 , 장혁 , 이계원 , 지웅길 ( Hyun Soon Choi , Jiang Ge , Gye Won Lee , Ung Kil Jee )
UCI I410-ECN-0102-2008-510-000811597

The captopril microcapsules were prepared and were investigated by measuring their size distribution using Scanning Electron Microscopy(SEM) and dissolution of captopril. Cetyl alcohol microcapsules prepared by emulsion melted-cooled method with various ratios of drug to cetyl alcohol were spherical and uniform. The release rate of cetyl alcohol microcapsules was decreased proportionally as the content of cetyl alcohol increased but, the particle size of microcapsules was increased. The surface of cetyl alcohol microcapsules was comparatively rough as drug content increased. Pellet type microcapsules were prepared using fluidized-bed coating system by spraying captopril solution on nonpareil-seeds followed by applying Eudragit^ⓡ RS solution containing propylene glycol as a plasticizer. The release rate of drug from pellet type microcapsules decreased as the content of Eudragit^ⓡ RS increased.

[자료제공 : 네이버학술정보]
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