An inclusion complex of muscone with β-cyclodextrin (CD), as a solid form of muscone, was prepared to increase the solubility of muscone. The molar ratio of muscone to β-CD in complex was in the range of 1:1∼1:5 when prepared by freeze-drying method: The interaction of muscone with β-CD in solid state was investigated by Infrared (IR) spectroscopy and differential scanning calorimetry (DSC). IR and DSC studies between muscone-β-CD inclusion complex and physical mixture showed that muscone-β-CD inclusion complex was prepared stably. From the amount of muscone incorporated in the inclusion complex, it was found that the molar ratio of muscone : β-CD was 1:1. Relative spatial position of muscone and β-CD was observed by Hyperchem molecular modelling program.