18.97.9.171
18.97.9.171
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난용성약물 Biphenyl Dimethyl Dicarboxylate의 제제화를 통한 용출증대
Enhancement of Dissolution Properties through Formulations of Insoluble Drug Biphenyl Dimethyl Dicarboxylate
이순아 , 송경 , 박은전 , 손동환 , 고건일 , 김재백 ( Soon Ah Lee , Kyung Song , Eun Jeon Park , Dong Hwan Sohn , Geon il Go , Jae baek Kim )
UCI I410-ECN-0102-2008-510-000812807

The dissolution characteristics of DDB were markedly enhanced by preparing solid dispersions of drug with polyethylene glycol 6000. Solid dispersions of various weight fraction were formed by a melting method. And various tablets(A∼E) were prepared from these solid dispersions with excipients (lactose, corn starch, Avicel and PVP) by wet granulation method. There were no significant differences in dissolution rates between physical mixture and DDB alone. But dissolution rates of solid dispersions were 1.4∼2.0 times greater than that of DDB alone and 1.2∼1.8 times greater than those of a commercial tablet.

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