We hypothesized that acellular dermal matrix (ADM) graft along with scar revision may act as a dermal regeneration substitute, and it will improve skin color, texture, humidification, and elasticity. We implanted acellular dermal matrix in subcutaneous layer of incision area during scar revision surgery for the successful treatment of various scars. In clinical study, we excised scar tissue measuring length and width of the scar (n=22), implanted the ADM underneath and closed the defect with appropriate approximation. Functional skin values of scar revision area and adjacent normal skin were evaluated in terms of skin elasticity, humidification, transepidermal water loss, and color. Also, patient satisfaction was assessed at postoperative 6 months with visual analog scale in terms of cosmetic satisfaction, pain or itching sensation and scar hardness. Patient`s survey revealed that patients were satisfied with the postoperative results showing 7.8 ± 1.1 of overall VAS score in all factors. Humidification of scar indicated that the score was 1.03 ± 0.3 (scar site per adjacent normal skin) at preoperative period and 1.52 ± 0.95 at 6 months. ADM could be adequate for use as a tissue remodeling substitute, and scar revision technique using ADM implantation is satisfactory in terms of high patient satisfaction and significantly improved humidification.