To increase the dissolution rate of furosemide, co-grinding or co-precipitating of furosemide with PVPP(polyvinyl polypyr rolidone) was carried out. The ground mixture of furosemide with PVPP was prepared by co-grinding in a ceramic ball mill and the coprecipitate was prepared by using methanol. The PVPP ground mixture and the coprecipitate showed a faster and more enhanced dissolution rate than the physical mixture or intact furosemide. The IR, DTA and TGA studies showed the physicochemical modifications of furosemide from the ground mixture and the coprecipitate. An interaction, in the ground mixture and in the coprecipitate, such as association between the functional groups of furosemide and PVPP might occur in the molecular level. The co-precipitating and cogrinding techniques with PVPP provided a promising way to increase the dissolution rate of poorly soluble drugs.