18.97.14.86
18.97.14.86
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수용성 담체와의 공침물 형성에 의한 메토클로프라미드의 용출 증가
Dissolution Enhancement of Metoclopramide by Coprecipitation with Water - Soluble Carriers
용재익(Jae Ick Yong), 정차옥(Cha Ok Jeong)
UCI I410-ECN-0102-2008-510-000812721

In order to increase the dissolution characteristics of relatively water-insoluble metoclopramide (MCP), coprecipitates of MCP with polyvinylpyrrolidone (PVP), polyethylene glycol (PEG) 1000, 4000 or 6000 were prepared in various drug to polymer ratios. The dissolution rate of MCP-PVP coprecipitate was greater than those of MCP alone, MCP-PVP physical mixture and MCP-PEG coprecipitates. The dissolution rate of MCP-PEG 6000 coprecipitate was greater than those of MCP-PEG 1000 and MCP-PEG 4000 coprecipitates. The dissolution half-lives (T_(50%)) for MCP alone and 1:5 (w/w) MCP-PEG 6000 coprecipitate were determined by the log-probit method at 37℃ and found to be 4.17 and 0.98 min, respectively.

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