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Flurbiprofen 용매침착물의 용출특성에 관한 연구
Studies on Dissolution Rate of Flurbiprofen from Solvent Depositon Systems
최보경(Bo Kyung Choi), 용재익(Jae Ick Yong)
약제학회지 vol. 15 iss. 3 100-112(13pages)
UCI I410-ECN-0102-2008-510-000813051

Dissolution characteristics of flurbiprofen solvent deposited on α-cyclodextrin, β-cyclodextrin, lactose and corn starch were studied to evaluate the pharmaceutical aspects of solvent deposition method where drug was solvent deposited on the surface of excipients. In a solvent deposition system, the drug to excipient ratio and kind of excipient affect much on dissolution rates of flurbiprofen. The solvent deposition system formation was confirmed by scanning electron microscope. By inereasing the amounts of matrix, it was possible to enhance the dissolution rate of flurbiprofen solvent deposition system. The amount of flurbiprofen dissolved from β-cyclodextrin deposition system (1 : 10) at 60 minutes was enhanced 6.5 times in water and 28 times in simulated gastric juice compared with flurbiprofen alone. Flurbiprofen solvent deposited system (1 : 10) enhanced dissolution rate greater than inclusion complex and dispersion system.

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