This study investigated social determinants and their interaction effects on the health of school-aged children in diverse environmental factors pertaining to the individual, family, and peers from an ecological systematic perspective. Data were drawn from the first wave of the Korean Children and Youth Panel Survey (KCYPS) developed by the National Youth Policy Institute and conducted in 2010. Data were analyzed by descriptive statistics, Cronbach a, correlation, and hierarchical regression analysis using SPSS ver. 18. The results from this study showed that sex and age were related to the health of school-aged children, as social determinants. Self-rated levels of the health of boys and younger children were more positive than girls and older children; in addition, levels of self-resilience, satisfaction of peer relation, and parenting rearing attitude were found to have a positive impact on self-rated levels of the health of school-aged children as protective factors. Especially, according to the result of interaction analysis between factors, self-resilience, and parenting rearing attitude were moderators of the effects on between sex and household income and self-rated level of the health of school-aged children respectively. The findings from this study suggested the need to expand the social intervention range to improve school-aged children`s health.