A ginseng preparation (GP) consisting of ginseng ex., lycium fructus ex., four kinds of vitamines and caffein was evaluated for acute toxicity and general pharmacology. Average lethal doses (LD_(50)) of GP in male mice were 2,988㎎/㎏ (i.p.) and more than 3g/㎏ (p.o.). In dosage of 300 and 900㎎/㎏ (p.o.) showed no analgesic activity in both tests of the writhing method induced by acetic acid and of tail pressure method and no effect on the pentetrazole-induced convulsion. However, it appeared to have a hypothermic action only in dose of 900㎎/㎏. The duration of hypnosis induced by hexobarbital sodium in mice was shortened by GP, being probably due to caffein. GP produced no marked contraction of isolated ileum and uterus in high concentrations of up to 1 × 10^(-3)g/㎖. These results suggested that GP did not show any considerable central nervous depressant activity and exhibited very weak actue toxicity in mice.