Spherical matrixes were prepared from liquid suspension. The drug (sulfamethoxazole) particles dispers ed in distilled water were agglomerated with a melt of matrix material (stearyl alcohol), so dense and free-flowing agglomerates were obtained. The factors affecting the average size, drug content and the release behavior of the resultant products were investigated. The geometric mean diameters and drug contents were affected primarily by the species of matrix, the amountof matrix, and drug particle-size used. In-vitro dissolution studies indicated that the drug was released as a first-order kinetic model. Ths release behaviors varied with the species of matrix, the amount of matrix, size fraction, and drug particle-size used. Steary alcohol proved to play the weak role of matrix in basic medium.