The intentional test of the clinical test on the mouse, which are orally administered salicylamide combined with chlorpheniramine maleate were made by writhing syndrome method of 0.7% acetic acid-saline solution and following effects were found. 1) The cross-over test of writhing syndrome method have intention in case of three days rest after the first examination. 2) The most active rate of salicylamide by administration combined with chlorpheniramine maleate is salicylamide 20㎎/㎏ : chlorpheniramine maleate 20㎎/㎏ (1:1) 3) The most active range of chlorpheniramine maleate used for assistant action of salicylamide is 15㎎/㎏∼20㎎/㎏