Having measured physical canstant and dissolution rate of prednisolone powder, and tablets, also particle size, particle number of powder disintegration, hardness, friability of prednisolone tablets and having also compared it`s interrelationship. We obtained the results as following. 1) Dissolution rate of prednisolone powder was determinded cube root rule and the slope (α) was 3.1915 × 10^(-2). 2) The tablet used in this study was fourteen kind of prednisolone tablets, two kinds of which were not conformity with prednisolone dissolution rate test of U. S. P. XVIII, but the rest of them were conformity with the same test (t60% was 4.3minute in average) 3) There was no significant interrelationship between disintegration, hardness, friability and dissolution rate of prednisolone tablet used in this study but we recognized the disintegration time was greatly influenced by the dissolution rate.