The comparative studies were made on the analgesic antipyretic effects of aminopyrine used individually and combined with parasympathetic agents(atropine sulfate). The analgesic antipyretic effects were eximined by Writhing`s method to the experimental groups(mouse), and the following effects were found: 1) The active intensity of aminopyrine by it`s oral administration combined with atropine sulfate is as follows. Amiinopyrine 80 ㎎/㎏ combided with Atropine sulfate 0.005 ㎎/㎏=Aminopyrine 100 ㎎/㎏ 2) The most active range of intensity of Atropine sulfate(adjuvant) by it`s oral administration is as follows. Atropine sulfate 0.004∼0.005 ㎎/㎏.