The change of brain activation due to the cognition of driving speed was investigated using functional Magnetic Resonance Imaging (fMRI). Eight healthy males (24.7±1.8 years) and eight healthy females (22.2±1.7 years) participated in the study. Video recorded in real driving conditions on the expressway at driving speeds of 50, 70, 90, and 110 km/h were shown as visual stimuli. Each session consisted of three blocks: each having a Low Speed phase (50km/h, 1 min) and a High Speed phase (70, 90, or 110 km/h, 1 min respectively). The area of activation and the number of activated voxels were extracted by subtraction method (Low Speed phase - High Speed phase). The areas related to visual and spatial attention such as temporal, occipital, parietal, frontal areas, and cerebellum were activated in the cognition of driving speed. As the high speed, the activation voxels also increased in the areas related to visual (the temporal area, occipital area, and cerebellum) and spatial attention (fronto-parietal area). However, while the activation voxels in the area related to spatial attention tended to increase in a linear, it did not in the areas related to visual. This implies that each brain area has a different level of involvement in the cognition of the driving speed, although both visual cognition related areas and spatial attention related area are related to it.