Purpose: The present study was done to identify the relationship of cultural competence, self efficacy and job stress of nurses working on wards for foreign patients. Methods: The participants were 133 clinical nurses who agreed to participate in the study and were working on wards for foreign patients in three general hospitals in Seoul. A structured questionnaire that covered the three tested constructs was conducted between Dec. 15, 2014 and Jan. 15, 2015. Data were analyzed using descriptive statistics, t-test, one-way ANOVA, and Pearson correlation coefficients with SPSS/WIN 21.0 program. Results: Cultural competence was found to have a significant positive correlation with self efficacy (r=.464, p<.001) and self efficacy had a significant negative correlation with job stress (r=-.397, p<.001). Conclusion: The findings of the study suggest that programs designed to nourish cultural sensitivity and cultural skills need to be developed in order to promote cultural competence. The results also suggest that in these programs to improve self efficacy and reduce job stress should be considered.