Purpose: It intends to examine the needs of educational simulation program for cancer patient nursing among nursing students and new nurses in the cancer ward. Methods: Through the focus group interview, 22 preliminary items were composed and its feasibility was examined by experts. The data were collected from 20 nursing students and new nurses working in the cancer ward respectively using SPSS 20.0. Results: The nursing students showed high demand in side-effects and effects of cytotoxic drug, cancer pain management, management of central venous catheterization and catheter, administration of cytotoxic drug, and management of emergent situation whereas the new nurses needed guidelines for safe handling of cytotoxic drugs, administration of cytotoxic drug, clinical decision and understanding priority, management of emergent situation, side-effects and effects of cytotoxic drug, management of central venous catheterization and catheter, and cancer pain management. Conclusion: Thus, study result reflected simulation program will help provide quality nursing service in clinical setting.