Eccrine hidrocystoma (EH) is benign proliferation of eccrine glands. They are commonly found in middle-aged to elderly women. EH may be solitary or multiple and are occasionally numerous. In case of single lesion, hidrocystomas may be removed by simple excision, electrodesiccation or CO2 laser. However, multiple EH is difficult to treat because of these methods could leave behind wounds. Multiple EHs treated with application of topical atropine or botulinum toxin A injection have been reported. Oxybutynin, well-known anticholinergics, is a high-affinity antagonist of M3 receptors localized in secretory glands. Therefore, it exerts an inhibitory effect on sweat glands, and often used in the treatment of hyperhidrosis. We report a case of multiple EH successfully controlled with oral oxybutynin. A 68-year-old female presented with numerous translucent papules with hyperhidrosis on both periorbital area for 10 years. The diagnosis of EH was made by histopathological examination. The patient started treatment with oral oxybutynin 5 mg once daily. After 4 week of therapy, a marked regression in lesions and symptom was noted. The patient is currently in a maintenance treatment. We suggest that the use of oral anticholinergics could be a potentially beneficial treatment option for hidrocystoma.