Kaposi’s sarcoma (KS) is a uncommon angioproliferative tumor involving blood and lymphatic vessels of mesenchymal origin. Human Herpes Virus 8 (HHV-8) infection is known to play a crucial role in the development of KS. An association with HIV infection has been also well noted. Clinically, KS are characterized by macules, plaques and nodules that are of a purple, red, blue, dark brown or black appearance. Although KS can affect mucocutaneous tissue and internal organs, isolated scrotal involvement of KS has rarely been reported. Herein, we present a case of scrotal KS in a patient without HIV. A 72-year-old man presented with asymptomatic, multiple, variable-sized, irregular-shaped, hyperpigmented, firm, nodules on the scrotum for 2 months. The patient was taking medication for hypertension and asthma. Histopathologic findings revealed dermal nodule with whorled bundles of spindle cells and slightly dilated vascular slits. Marked cellular atyipism with eosinophilic intra- and extracellular globules was also observed. These findings were consistent with Kaposi’s sarcoma. The patient is under investigation for other organ involvement, operability and HHV-8 infection. While classical KS is usually observed in the lower limbs, it can rarely affect scrotal skin as isolated lesions. Herein, we report a rare case of KS affecting the scrotum of a 72-year old male.