Cutaneous involvement of multiple myeloma is very rare as less than 1% of myeloma patients. The most common cutaneous involvement is resulted from direct extension to the skin from bony lesions. A hematogenous or lymphogenous skin metastasis is more rare. A 56-year-old woman presented with dermal nodules on both arms, abdomen and buttock for 7 days. She had been diagnosed with multiple myeloma and taken autologous peripheral blood stem cell transplantation 3 years ago. She also has been receiving chemotherapy for 3 years. On histopathological examination, there were some atypical plasmacytic infiltrations in the subcutaneous fat which also could be identified with CD38 staining. It was diagnosed as cutaneous involvement of multiple myeloma. The patient received chemotherapy and skin lesions decreased in size. Cutaneous involvement of multiple myeloma may appear in any area of the skin, but it has been reported most commonly on the trunk, followed by the scalp, face, and neck, lower extremities, and upper extremities. On average, death of most patients occurred within 12months after the diagnosis. Herein, we report a rare case of cutaneous involvement of multiple myeloma.