Leukemia cutis(LC) is a cutaneous eruption resulting from a specific infiltration of the skin by leukemic cells. LC is frequently seen in patients with myelodysplastic syndrome concomitantly with identifiable leukemic transformation in the peripheral blood or bone marrow. A 60-year-old female patient without any known prior disorder had erythematous ill-defined maculopapules, nodules on her trunk at the time of the first visit. Punch biopsy and blood test were performed. Histopathologically, H&E stain showed mild perivascular and interstitial lymphohistiocytic infiltration mimicking inflammatory diseases. Repeated complete blood count showed leukocytosis with increased band form neutrophils, monocytes, metamyelocytes, promyelocytes and anemia, thrombocytopenia. Immunohisto-chemistry and serial sections showed postive for CD43, CD45, CD56, myelo- peroixidase, lysozyme, negative for CD3, CD8, CD20 and perivascular monocytoid infiltration, several pleomorphic mononuclear cells between collagen bundles, respectively. After 2 months, the diagnosis of acute myelogenous leukemia (AML) had been confirmed by bone marrow examination. Case with minimal infiltrates may be mistaken for inflammatory dermatoses and represent a pitfall in the histopathological diagnosis of cutaneous manifestation of AML. The development of cutaneous leukemic infiltrates is a harbinger of acute leukemia within 1-20 months of diagnosis of the skin lesion.