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18.97.14.90
18.97.14.90
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A case of leukemia cutis, the initial sign of acute myelogenous leukemia
( Sookkyung Lee ) , ( Woojung Jin ) , ( Wooseok Jeong ) , ( Seunghyun Moon ) , ( Taekgeun Lee ) , ( Taegwang Kwon )
UCI I410-ECN-0102-2017-510-000102650
This article is 4 pages or less.

Leukemia cutis(LC) is a cutaneous eruption resulting from a specific infiltration of the skin by leukemic cells. LC is frequently seen in patients with myelodysplastic syndrome concomitantly with identifiable leukemic transformation in the peripheral blood or bone marrow. A 60-year-old female patient without any known prior disorder had erythematous ill-defined maculopapules, nodules on her trunk at the time of the first visit. Punch biopsy and blood test were performed. Histopathologically, H&E stain showed mild perivascular and interstitial lymphohistiocytic infiltration mimicking inflammatory diseases. Repeated complete blood count showed leukocytosis with increased band form neutrophils, monocytes, metamyelocytes, promyelocytes and anemia, thrombocytopenia. Immunohisto-chemistry and serial sections showed postive for CD43, CD45, CD56, myelo- peroixidase, lysozyme, negative for CD3, CD8, CD20 and perivascular monocytoid infiltration, several pleomorphic mononuclear cells between collagen bundles, respectively. After 2 months, the diagnosis of acute myelogenous leukemia (AML) had been confirmed by bone marrow examination. Case with minimal infiltrates may be mistaken for inflammatory dermatoses and represent a pitfall in the histopathological diagnosis of cutaneous manifestation of AML. The development of cutaneous leukemic infiltrates is a harbinger of acute leukemia within 1-20 months of diagnosis of the skin lesion.

[자료제공 : 네이버학술정보]
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