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Herpes zoster with meningitis in a vaccinated, immunocompetent child
( Soo Kyung Lee ) , ( Dong Joo Kim ) , ( Joong Heon Suh ) , ( Myoung Shin Kim ) , ( Un Ha Lee )
프로그램북 68권 1호 413-413(1pages)
UCI I410-ECN-0102-2017-510-000102256
이 자료는 4페이지 이하의 자료입니다.

Neurologic complications from varicella zoster virus (VZV) reactivation are rare and mainly reported in immunocompromised patients after reactivation of wild-type varicella-zoster virus. In this report, we describe a previously immunized healthy child who developed herpes zoster with meningitis. A 7-year-old boy visited our clinic with painful, itchy skin rash on left face, fever, headache, and vomiting. After admission, he showed meningeal irritation sign and lumbar puncture was performed. Cerebrospinal fluid examination showed an increased protein concentration (51 mg/dL), white blood cells (200 WBC/mm3, 98% lymphocytes) and VZV DNA was detected by polymerase chain reaction. A review of his immunization record showed a varicella vaccination at 1, 2months of age and the results of immunological screening for HIV, serum immunoglobulin and complement levels were unremarkable. Acyclovir was administered intravenously at a dose of 15 mg/kg every 8 hours for 10days and the patient’s clinical condition rapidly improved. Repeated CSF PCR for VZV converted to negative on hospital day 10, he was discharged and was asymptomatic with a normal physical examination at 3 weeks later. Vaccine strain VZV becomes currently important cause of herpes zoster and meningitis among immunized children, so we should aware varicella zoster vaccine have potential for reactivation and complications in both immunocompetent and immunocompromised hosts. Keyword: Herpes zoster meningitis, Child, Vaccinated.

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