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A case of ischemic ulcers in systemic sclerosis
( Byeol Han ) , ( Sook Ja Son ) , ( June Hyunkyung Lee ) , ( Tae Young Han )
UCI I410-ECN-0102-2017-510-000107564
This article is 4 pages or less.

Systemic sclerosis (SSc) is a chronic autoimmune disease of the connective tissue characterized by vasculopathy and organ fibrosis. In addition to life-threatening organ involvement, skin ulcers are important complications severely affecting the quality of life and activity of daily living in SSc. Especially digital ulcers are considered as a sentinel sign for early organ involvement in very early diagnosis of SSc. A 59-year-old woman presented with 3-month history of persistent multiple digital ulcers on her fingers tip. She had episodes of Raynaud phenomenon, with severe pain, numbness, and cyanosis when exposed to the cold. Also, multiple ulcers with crust and livedo reticularis along the both lower legs were noted. Laboratory evaluation revealed a positive antinuclear antigen of 1:320 and a strongly positive anti-scl-70 antibody confirming the diagnosis of diffuse systemic sclerosis. Histopathologic examination from ischemic ulcerative lesions on the finger tip and lower leg showed ulcer and prominent increased collagen bundles which is consistent with systemic sclerosis. Treatment with systemic vasodilators, cyclophosphamide, glucocorticoid and closed dressing led to resolution of skin lesions. Herein, we report a case of ulcerative lesions in systemic sclerosis. Ischemic ulcerative skin lesions especially on the digits should be evaluated whether it is related to autoimmune disorders such as systemic sclerosis.

[자료제공 : 네이버학술정보]
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