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Eosinophilic fasciitis
( Hyeree Kim ) , ( Yu Seok Jung ) , ( Sang Hyun Cho ) , ( Jeong Deuk Lee ) , ( Hei Sung Kim )
프로그램북 68권 1호 349-349(1pages)
UCI I410-ECN-0102-2017-510-000080166
이 자료는 4페이지 이하의 자료입니다.

A 52-year-old man presented with diffuse stiffness and immobility of the right forearm for 6 months. Physical examination showed diffuse contraction and induration with linear depressions on the Rt. arm. The MRI scan showed increased signal intensity in the fasciae. Histopathologic findings revealed thickened fascia with dense mononuclear infiltrate. From the findings, the diagnosis of eosinophilic fasciitis was made. The patient showed dramatic improvement after treatment with prednisolone (30mg/day) and methotrexate (12.5mg/week). Eosinophilic fasciitis (EF) is an uncommon connective tissue disease characterized initially by edematous and erythematous extremities, followed by peau d’orange pigmentation and induration. Linear depressions known as the “groove sign” often occur within the thickened skin following the course of the underlying vessels. The differential diagnosis of EF include systemic sclerosis, scleredema, and scleromyxedema. Although the etiology of EF remains unclear, it is known to be associated with vigorous exercise, drugs, Borrelia infection, and various hematological and autoimmune diseases. Laboratory examinations may reveal peripheral eosinophilia, hypergammaglobulinemia, and elevated erythrocyte sedimentation rate (ESR). The gold standard of EF treatment is high-dose corticosteroid. Other effective treatments include hydroxychloroquine and methotrexate. We herein report a rare case of eosinophilic fasciitis.

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