Kimura’s disease is a rare chronic inflammatory disorder common in the head and neck. Patients usually present with painless slowly enlarging subcutaneous masses with lymphadenopathy. Peripheral blood eosinophilia and elevated serum immunoglobulin(Ig)E levels are also common. Histopathologically, this tumor is composed of vascular proliferation and lymphoid infiltrate rich in eosinophils. Treatment includes surgical resection and regional or systemic steroid therapy. Cytotoxic therapy and radiation have also been utilized. However, antibiotic therapy has not been reported. The disease has an excellent prognosis, although it may recur locally. A 53-year-old man presented with 6-month history of asymptomatic slow growing multiple variable sized, skin colored subcutaneous nodules. The laboratory examination showed peripheral eosinophilia (30%) and increased serum IgE level. Multiple anechoic cystic lesions with posterior acoustic shadowing were seen on ultrasonography. Histopathologic examinations showed extensive infiltration of lymphocytes and proliferation of irregularly shaped blood vessels embedded in a dense infiltration composed of small lymphocytes, plasma cells, histiocytes, and eosinophils in the subcutaneous layer. After treatment with oral cephalosporine (750mg/day) for 4 weeks, skin lesions were resolved. Herein, we report a case of Kimura’s disease on the right preauricular area which is treated with cephalosporine.