Atopoic dermatitis(AD) and contact dermatitis are common eczematous disorders mediated inflammatory mechanisms. As with other eczematous disorders, they are both characterized by serous accumulation in the epidermis and dermal inflammatory infiltrate, expressed clinically as erythema, with or without concomitant edema and/or blistering Despite differing etiologies, AD and contact dermatitis have been the focus of many studies examing the potential association of the two condition The relationship of contact allergy of patients with AD is complex, and the incidence of ACD with AD is unknown. There still is conflicting evidence as to whether patients with AD are at a higher overall risk of contact sensitization compared with non atopic dermatitides. In the past, it was believed that patients suffering from AD were less likely to suffer from ACD. It was traditionally believed that patients with AD are not capable of developing CD due to a shift away from cytokines that are responsible for delayed hypersensitivity responses. However, more recent studies indicated that ACD is equally prevalent among atopics and nonatopics. Patients with AD have impaired skin barrier function that may potentially increase allergen penetration. Mutations in the fillaggrin gene have been associated with occupational chronic irritant CD in some studies. The patient with AD also is exposed to numerous topical treatments, including lotions, creams, ointments, and medications, often on a long-term daily basis. Current research also indicates that AD patients may be more prone to suffer from ICD. Understanding the potential links between AD and contact dermatitis, and the parallel aspects of their pathogenesis can be helpful to clinicians caring for patients suffering from the disorders.