The aim was to evaluate the clinical findings of patients who admitted to the hospital with the diagnosis of grayanotoxin poisoning. 13 patients of total (25)were female (52%). Mean age was 55.4. The most frequently observed findings were nausea-vomiting (100%), dizziness (72%), generalized weakness (44%) and chest discomfort (40%). Average heart rate was 52.2 BPM. On the initial EKG, sinus bradycardia was observed in 20 patients. 3rd degree AV block and preexcitation were revealed in 3 and 1 patients, respectively. Mean SBP and DBP were 76.4 mmHg and 47.2 mmHg, respectively. The mean time to onset of symptoms was 1.2 h. LOS in hospital was 16.0 h. All patients were discharged from the ED after symptomatic management. Sources of Grayanotoxin were R.brachycarpum, R.mucronulatum, R.schlippenbachii and Himalaya mad honey. SBP in poisoning by non- mad honey was decreased significantly in comparing with mad honey group. Dizziness and blurred vision were more frequent symptoms and signs in mad honey group. When patients with no specific medical history visit a hospital with reports of toxidrome including bradycardia, hypotension, nausea-vomiting, dizziness, chest discomfort or blurred vision, it is advisable to confirm whether they have ingested mad honey or a decoction or any wine made from rhododendron spp. This may make it possible to avoid unnecessary examination and to provide quick treatment for these patients.