This stuty was studied in 42 healthy young men and 31 healthy young women by Espette method for normal reference value of ESR in this laboratory and also in 125 randomly selected patients for comparison of ESR between the Espette method and Wintrobe method. The normal reference value of young man was 0 to 12 mm/hr and the normal reference value of young woman was 0 to 23 mm/hr. So the nomal reference value of ESR were higher in woman than in man. In comparison of ESR of patient group, ESR by Wintrobe method was higher than by Espette method (P < 0.05) and correlation of two method was show high degree (r=0.865, r=0.939, r=0.846, r=0.915) This Espette method consist of disposable plastic tubes is more convenient and safe technique for measuring the ESR, because a dilution step is not involed and it requires less sample. Furthermore, the confusing affects of anemia can be avoided, because adequate hematocrit corrections can he applied.