Recombinant DNA technology was applied to scientifically gifted high school students using developed laboratory teaching materials. As a result, they successfully performed all experiments. Through laboratory activities they showed a significant increase in understanding of concepts of genetic engineering (p=0.007). In the survey of questionnaire it was known that they were strongly influenced on intellectual inquiry and interest of biology through laboratory activities of recombinant DNA technology. In questionnaire ninety four percents of students answered that laboratory activities of recombinant DNA technology helped their understanding about genetic engineering, and students hoped that experiments of recombinant DNA technology were included into the content of textbook.