Objectives: The purpose of the study is to investigate the relationship between the number of remaining teeth and depression in Korean adults. Methods: The subjects were the respondents of the Sixth Korea National Health and Nutrition Examination Survey(KNHANES). The questionnaire consisted of the general characteristics of the subjects, number of remaining teeth, and prevalence of depression. relationship of the prevalence of depression and the number of remaining teeth. The data were analyzed by chi-square test, t-test, and logistic regression using SPSS, and 95% confidence intervals were calculated. Results: There was a significant difference in number of remaining teeth and odds ratio(OR) was 1.940(95% confidence interval: 1.062-3.544). Statistically significant difference was not observed after adjusting for age and gender and OR was 1.515(95% confidence interval: 0.823-2.787). And Statistically significant difference was not observed after adjusting for age, gender and other variables. The OR was 1.399(95% confidence interval: 0.757-2.586). Conclusions: Depression in the adults was related to the number of remaining teeth. But there was no significant difference in the number of remaining teeth after adjusted for age, gender, and other factors.