Purpose -The purpose of this paper is to explore the relationships between Six Sigma practices and different types of organizational innovation including product innovation, process innovation and administrative innovation. Design/methodology/approach - Empirical data were collected from 249 firms in China which had implemented Six Sigma as a formal program in their organization. Structural Equation Modeling was used to test the hypothesized relationship between Six Sigma practices and innovation. Finding -The results show that Six Sigma management, infrastructure, and core practices have a positive relationship with product, process and administrative innovation. Originality/value -This study contributes to a better understanding of how firms can take advantage of the Six Sigma implementation to improve their capacity in innovation.