Purpose: The purpose of this paper is to explore the role of core and infrastructure Quality Management (QM) practices in ambidexterity. The paper discusses how these QM practices contribute to ambidexterity and develops propositions about their unique roles in ambidexterity. Methodology/Approach: Based on a review of literature this conceptual paper explores the role of core and infrastructure QM practices in ambidexterity. The paper then develops propositions about the modus operandi of each type of QM practices in causing ambidexterity. Findings: Core and Infrastructure QM practices can support exploitation and exploration and therefore contribute to ambidexterity. Core QM practices have a direct positive role in ambidexterity; whereas infrastructure QM practices have an indirect positive role in ambidexterity through core QM practices. Research limitations: Being a conceptual paper the propositions developed in this paper need empirical testing. Cross-sectional research such as surveys based on large sample size should investigate the relations proposed in this study, i.e., relationship between QM practices and ambidexterity. Originality/Value of paper: The key contribution of this paper is two folds: first it elaborates the role of core and infrastructure QM practices in ambidexterity. Given the fact that the role of QM in ambidexterity is an emerging topic, a discussion on this role is a genuine contribution. Second, the development of propositions is an important milestone towards developing a theory of ambidexterity through QM.