Objectives: Although pneumonia is associated with an increased risk of venous thromboembolism (VTE), patients with pulmonary embolism (PE) and concomitant pneumonia are uncommon. The aim of the present study was to investigate the clinical features of PE with coexisting pneumonia. Methods: We retrospectively compared clinical, radiologic, and laboratory parameters between patients with PE and concomitant pneumonia (pneumonia group) and those with unprovoked PE (unprovoked group), and then between the pneumoniagroup and those with pulmonary infarction (infarction group). Results: Of 794 patients with PE, 36 (5%) had coexisting pneumonia and six (1%) had no provoking factor other than pneumonia. Stroke was significantly more common in the pneumonia group, ascompared with either the unprovoked groupor the infarction group. In the pneumonia group, fever was significantly more common and serum C-reactive protein levels weresignificantly higher. By contrast, central PE and right ventricular dilation on computed tomography were significantly less frequent in the pneumonia group. In addition, an adverse outcome due toPE was less common in the pneumonia group than in either of the other two groups. Conclusions: The coexistence of PE and pneumonia is rarely encountered in clinical practice, especially without the presence of other factors that could provoke VTE and is commonly associated with stroke. It is characterized by lower incidences of central PE and right ventricular dilation and by a lower rate of adverse outcomesdue to PE itself.