Due to its abundant reserves, methane is called as a next-generation carbon feedstock for the production of chemicals and fuels. In order to make chemicals and fuels from methane, C-H bond of methane needs to be activated. Methane converts methane to methanol via activation of oxygen and then into C-H bond, resulting in formation of methanol. Methanol is platform chemicals that can be used for the synthesis of variety of chemicals and fuels. In this presentation, methanotrophcatalyzed bioconversion of methane to methanol will be presented.