Purpose: This study was to investigate the resuscitation outcomes and the clinical characteristics of non-traumatic drug-induced out-of-hospital cardiac arrest by analyzing data from a single institution’s registry. Method: We conducted a retrospective study of 795 patients who came to the emergency department with nontraumatic drug-induced out-of-hospital cardiac arrest during the period 1991~2004. Only patients over 18 years of age were included. Clinical characteristics, variables associated with cardiac arrest, and data during resuscitation were obtained from our cardiac arrest database. Patients were divided into two groups: drug-induced cardiac arrest (drug group, n=33), and non drug-induced cardiac arrest (non-drug group, n=762). Results: Spontaneous circulation was restored in 23 (72%) patients in the drug group and in 314 (45%) patients in the non-drug group (χ2=0.020). The patients who discharged alive number were 46 (6%) in the non-drug group and 0 (0%) in the drug group (χ2=0.005). The witnessed arrest, the epinephrine doses, and total defibrillation energy were not different between two groups. Conclusion: The return of spontaneous circulation rate was higher in the drug group than the non-drug group. However the drug group was lower survival discharge rate than in the non-drug group.