The incidence of signet ring cell carcinoma accounts for approximately 10% of gastric cancer. Signet ring cell carcinoma of stomach does not metastasize to adjacent organ like duodenum or esophagus. We report a case of metastasis of esophagus and duodenum from signet ring cell carcinoma of the stomach. A 80 year-old female was admitted to St. Paul’s Hospital complaining of nausea and poor oral intake for 1 month. Her vital sign was stable and there were no significant findings on physical examination. Laboratory studies showed WBC 6,900 Hb 10.1 Plt 85,000 BUN/Cr. 11.1/0.74 Total protein/Albumin 4.13/2.34 Total bilirubin 0.89 AST/ALT 22/9 Na/K/Cl 139/3.5/106 LDH 811. Endoscopic finding revealed less than 1 cm sized multiple whitish nodular lesions with exudates in lower esophagus, entire stomach and bulbof duodenum. The 3 cm sized ulcerative lesion existed in prepyloric antrum (Fig. 1). The Histologic finding of the lesions was signet ring cell carcinoma. Abdomen CT finding showed no clearly visible mass except for multiple metastatic lymphadenopathies. PET-CT showed no FDG uptake lesion except esophagus, stomach, duodenum and lymphadenopathies in abdomen. Therefore, it is reasonable to believe that signet ring cell carcinoma originated in stomach metastasized to esophagus and duodenum. To the best of our knowledge, it is the first case of signet ring cell carcinoma that metastasized linearly to esophagus and duodenum.