Introduction: Colonic lipoma is uncommon and frequently asymptomatic, however, large lipoma is likely to cause complications, such as abdominal pain, lower gastrointestinal bleeding, obstruction, or intussusception. Mobile cecum is characterized by abnormal mobility of the cecum and ascending colon caused by a failure to fuse to the posterior parietal peritoneal wall. Although mobile cecum was found in 11.2% of autopsy, it rarely develops symptomatic disease such as volvulus or recurrent right lower abdominal pain. Here we report an unusual presentation of lipoma induced colo-colic intussusception in a patient with mobile cecum. Case: A 49-year-old man visited local clinic with intermittent upper abdominal pain and watery diarrhea for 3 days. He had a medical history of asymptomatic colonic lipoma in cecum, which was found in abdominal computed tomography(CT) 2 months ago. Physical examination and abdominal sonography showed non-specific finding. However, his pain had been aggravated and upper abdominal mass was palpable after 7 days. Follow up abdominal sonography revealed 3.6 cm sized mass on upper abdomen. He was referred to our hospital under suspicion of acute pancreatitis with pseudocyst. On laboratory findings, WBC count was 10,770/uL (neutrophil 79.7%.), but liver function test, amylase, lipase and electrolytes were normal range. After admission, he exhibited hematochezia. A repeated abdominal CT showed a colonic intraluminal fatty mass with associated intussusception of the mesentery at the level of the distal transverse colon. At laparotomy, colo-colic intussusception was found and cecum was invaginated into distal transverse colon. After manual reduction of intussusception, right hemi-colectomy with ileocolic anastomosis was performed. Pathology of the resected cecum showed a 5.5 × 4.5 × 4.5-cm semi-pedunculated submucosal tumor, which was consisted of yellowish fatty tissue. The patient had an uneventful post-operative recovery and remains well. Conclusions: Lipoma in mobile cecum can cause colo-colic intussusception in distant area of colon due to abnormal cecal mobility. If known cecal lipoma is presented as intussusception at different colonic region, mobile cecum syndrome should be suspected.