Background: A cream from mucus secreted by snails has 80% of mucin of snail. It contains glycosaminoglycan, allatoin for skin rejuvenation, glycolic acid for keratin removal, collagen and elastin, which are the components of dermis. Objectives: The aim of this study was to evaluate the efficacy of cream containing the mucus secreted by snails in reducing wrinkles, improving skin elasticity, density of dermis and lifting.Methods: Cream containing the mucus secreted by snails was applied to lateral epicanthal areas and left cheek of 10 subjects for 4 weeks. Wrinkles, improvement of skin elasticity, dermal density and lifting were evaluated at base, every 2 and 4 weeks. Satisfaction survey by patients was done after 4 weeks. Results: Comparing the changes between base and 4-week-result after applying cream, there were statistically significant improvement in wrinkles, skin elasticity, density of dermis and lifting.Conclusion: The treatment of cream containing the mucus secreted by snails seems to be effective in anti-aging treatment. However, long-term follow-up such as 3 or 6 months for confirmation of treatment efficacy should be established through further clinical trials involving a larger number of patients.