The important merit of Bi-22I2/Ag wire is to apply cable as round wire state. Bi-22I2 high Tc superconducting wires were fabricated in order to apply Rutherford cable near the future. Various Ag ratio from 0.22 to 0.42 of Ag tubes for PID (powder-In-Tube) process were used to investigate the workability and to prevent breakage of filaments during drawing. In order to find proper heat treatment condition, we investigated micro-structure of Bi-22I2/Ag wires by using differential thermal analysis, XRD and SEM. The effect of atmosphere on the peritectic decomposition temperature of precursor was investigated. The shape of grain was observed by SEM to investigate Bi-22I2 phase formation in filaments. The higher of Ag ratio of mono filament had the higher critical current density, Jc. The wire with 0.42 of Ag ratio showed 7,886 Alcm2 of Jc at 77K.