Cyclophosphamide is a derivative of nitrogen mustard and is used as an antineoplastic agent to treat leukemia, lymphoma, Hodgkin disease, multiple myeloma, sarcoma, and solid organ cancers. Cyclophosphamide can causes hyperpigmented patches after 4 weeks of therapy on the palms, soles, nails, teeth and, rarely, the gingiva. A 29-year-old man presented with two week history of multiple brown-colored macules on the whole body, especially on the face and hand. He was treated with 875mg of cyclophosphamide for acute lymphoid leukemia. Histopathology showed the superficial perivascular lymphocytic infiltration and increased dermal melanocyte and melanin in the basal laser. The patients underwent 3 sessions of pulsed dye laser. The hyperpigmented lesion started to resolve after the laser therapy and the withdrawal of cyclophosphamide.