Erythema nodosum is considered to be a hypersensitivity reaction to the various conditions. Vaccination related erythema nodosum is uncommon but hepatitis B virus, human papillomavirus, tetanus, diphtheria and pertussis, rabies, smallpox, typhoid and cholera and Bacille-Calmette-Guerin vaccination associated cases were reported. A 33-year-old Korean woman presented with 3 days history of painful erythematous plaques on both lower legs and knees. She received pneumococcal polysaccharide conjugate vaccine(Prevenar13®) before the skin rash. Histological examination of the left lower leg lesion revealed septal panniculitis without vasculitis. Erythema nodosum caused by pneumococcal vaccination has not previously been reported. It is important for clinicians to be aware of this rare, yet potential, adverse effect to pneumococcal vaccine.